APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

Haney MS*, Pálovics R*, Munson CN, Long C, Johansson P, Yip O, Dong W, Rawat E, West E, Schlachetzki JC, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T. Nature. 2024. (* equal contribution).

Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging.

Haney MS, Shankar A, Hsu I, Miyauchi M, Pálovics R, Khoo HM, Igarashi KJ, Bhadury J, Munson C, Mack PK, Tan T, Wyss-Coray T, Nakauchi H, Wilkinson AC. BioRxiv. 2022.

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T. Nature Neuroscience. 2020.

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

Pluvinage JV, Haney MS, Smith BA, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T. Nature. 2019.

Systematic identification of general and context-specific regulators of phagocytosis using magnetic genome-wide CRISPR screens

Haney MS*, Bohlen CJ*‡, Morgens DW, Ousey J, Barkal AA, Tsui K, Li A, Ego B, Collins H, Tucker A, Crane E, Boyle E, Jiang L, Chan J, Vorselen D, Labitigan L, Levin R, Bell G, Grinstein S, Collins S, Pritchard JK, Greenleaf WJ, Weissman IL, Theriot JA, Li B, Snyder MP, Barres BA‡, Bassik MC‡. Nature Genetics. 2018. (* equal contribution, ‡ co-corresponding).

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity

Kramer NJ*, Haney MS*, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui KC, Hertz NT, Tessier-Lavigne M, Bassik MC‡, Gitler AD‡. Nature Genetics. 2018. (* equal contribution, ‡ co-corresponding).